Botulinum toxin injections reduce associative plasticity in patients with primary dystonia
Identifieur interne : 001782 ( Main/Exploration ); précédent : 001781; suivant : 001783Botulinum toxin injections reduce associative plasticity in patients with primary dystonia
Auteurs : Maja Kojovic [Royaume-Uni, Slovénie] ; Antonio Caronni [Royaume-Uni, Italie] ; Matteo Bologna [Royaume-Uni, Italie] ; John C. Rothwell [Royaume-Uni] ; Kailash P. Bhatia [Royaume-Uni] ; Mark J. Edwards [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-06.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Aged, Anti-Dyskinesia Agents (administration & dosage), Bontoxilysin, Botulinum Toxins (administration & dosage), Dystonia, Dystonic Disorders (drug therapy), Dystonic Disorders (physiopathology), Electromyography, Female, Human, Humans, Injections, Intramuscular, Male, Middle Aged, Motor Cortex (drug effects), Motor Cortex (physiopathology), Neck Muscles (innervation), Neck Muscles (physiopathology), Nervous system diseases, Neuronal Plasticity (drug effects), Paired stimulation, Plasticity, Severity of Illness Index, Somatosensory Cortex (drug effects), Somatosensory Cortex (physiopathology), TMS, Torticollis (drug therapy), Torticollis (physiopathology), Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, botulinum toxin, cervical dystonia, cortical plasticity, paired associative stimulation, primary dystonia, transcranial magnetic stimulation.
- MESH :
- chemical , administration & dosage : Anti-Dyskinesia Agents, Botulinum Toxins.
- drug effects : Motor Cortex, Neuronal Plasticity, Somatosensory Cortex.
- drug therapy : Dystonic Disorders, Torticollis.
- innervation : Neck Muscles.
- physiopathology : Dystonic Disorders, Motor Cortex, Neck Muscles, Somatosensory Cortex, Torticollis.
- Adult, Aged, Electromyography, Female, Humans, Injections, Intramuscular, Male, Middle Aged, Severity of Illness Index, Transcranial Magnetic Stimulation.
Abstract
Botulinum toxin injections ameliorate dystonic symptoms by blocking the neuromuscular junction and weakening dystonic contractions. We asked if botulinum toxin injections in dystonia patients might also affect the integrity of sensorimotor cortical plasticity, one of the key pathophysiological features of dystonia. We applied a paired associative stimulation protocol, known to induce long‐term potentiation–like changes in the primary motor cortex hand area to 12 patients with cervical dystonia before and 1 and 3 months after botulinum toxin injections to the neck muscles. Primary motor cortex excitability was probed by measuring transcranial magnetic stimulation‐evoked motor evoked potentials before and after paired associative stimulation. We also measured the input–output curve, short‐interval intracortical inhibition, intracortical facilitation, short afferent inhibition, and long afferent inhibition in hand muscles and the clinical severity of dystonia. Before botulinum toxin injections, paired associative stimulation significantly facilitated motor evoked potentials in hand muscles. One month after injections, this effect was abolished, with partial recovery after 3 months. There were significant positive correlations between the facilitation produced by paired associative stimulation and (1) the time elapsed since botulinum toxin injections and (2) the clinical dystonia score. One effect of botulinum toxin injection treatment is to modulate afferent input from the neck. We propose that subsequent reorganization of the motor cortex representation of hand muscles may explain the effect of botulinum toxin on motor cortical plasticity. © 2011 Movement Disorder Society
Url:
- https://api.istex.fr/document/57C880D70CE37C0CFBB560043D227B26DB43FAD6/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235250
DOI: 10.1002/mds.23681
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-06">2011-06</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1282">1282</biblScope><biblScope unit="page" to="1289">1289</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">57C880D70CE37C0CFBB560043D227B26DB43FAD6</idno><idno type="DOI">10.1002/mds.23681</idno><idno type="ArticleID">MDS23681</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anti-Dyskinesia Agents (administration & dosage)</term><term>Bontoxilysin</term><term>Botulinum Toxins (administration & dosage)</term><term>Dystonia</term><term>Dystonic Disorders (drug therapy)</term><term>Dystonic Disorders (physiopathology)</term><term>Electromyography</term><term>Female</term><term>Human</term><term>Humans</term><term>Injections, Intramuscular</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (drug effects)</term><term>Motor Cortex (physiopathology)</term><term>Neck Muscles (innervation)</term><term>Neck Muscles (physiopathology)</term><term>Nervous system diseases</term><term>Neuronal Plasticity (drug effects)</term><term>Paired stimulation</term><term>Plasticity</term><term>Severity of Illness Index</term><term>Somatosensory Cortex (drug effects)</term><term>Somatosensory Cortex (physiopathology)</term><term>TMS</term><term>Torticollis (drug therapy)</term><term>Torticollis (physiopathology)</term><term>Transcranial Magnetic Stimulation</term><term>Transcranial magnetic stimulation</term><term>botulinum toxin</term><term>cervical dystonia</term><term>cortical plasticity</term><term>paired associative stimulation</term><term>primary dystonia</term><term>transcranial magnetic stimulation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Dyskinesia Agents</term><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Cortex</term><term>Neuronal Plasticity</term><term>Somatosensory Cortex</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonic Disorders</term><term>Torticollis</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Neck Muscles</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonic Disorders</term><term>Motor Cortex</term><term>Neck Muscles</term><term>Somatosensory Cortex</term><term>Torticollis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Injections, Intramuscular</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Bontoxilysin</term><term>Dystonie</term><term>Homme</term><term>Pathologie du système nerveux</term><term>Plasticité</term><term>Stimulation couplée</term><term>Stimulation magnétique transcrânienne</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Botulinum toxin injections ameliorate dystonic symptoms by blocking the neuromuscular junction and weakening dystonic contractions. We asked if botulinum toxin injections in dystonia patients might also affect the integrity of sensorimotor cortical plasticity, one of the key pathophysiological features of dystonia. We applied a paired associative stimulation protocol, known to induce long‐term potentiation–like changes in the primary motor cortex hand area to 12 patients with cervical dystonia before and 1 and 3 months after botulinum toxin injections to the neck muscles. Primary motor cortex excitability was probed by measuring transcranial magnetic stimulation‐evoked motor evoked potentials before and after paired associative stimulation. We also measured the input–output curve, short‐interval intracortical inhibition, intracortical facilitation, short afferent inhibition, and long afferent inhibition in hand muscles and the clinical severity of dystonia. Before botulinum toxin injections, paired associative stimulation significantly facilitated motor evoked potentials in hand muscles. One month after injections, this effect was abolished, with partial recovery after 3 months. There were significant positive correlations between the facilitation produced by paired associative stimulation and (1) the time elapsed since botulinum toxin injections and (2) the clinical dystonia score. One effect of botulinum toxin injection treatment is to modulate afferent input from the neck. We propose that subsequent reorganization of the motor cortex representation of hand muscles may explain the effect of botulinum toxin on motor cortical plasticity. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li><li>Royaume-Uni</li><li>Slovénie</li></country><region><li>Latium</li><li>Lombardie</li></region><settlement><li>Milan</li><li>Rome</li></settlement></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Kojovic, Maja" sort="Kojovic, Maja" uniqKey="Kojovic M" first="Maja" last="Kojovic">Maja Kojovic</name></noRegion><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><name sortKey="Bologna, Matteo" sort="Bologna, Matteo" uniqKey="Bologna M" first="Matteo" last="Bologna">Matteo Bologna</name><name sortKey="Caronni, Antonio" sort="Caronni, Antonio" uniqKey="Caronni A" first="Antonio" last="Caronni">Antonio Caronni</name><name sortKey="Edwards, Mark J" sort="Edwards, Mark J" uniqKey="Edwards M" first="Mark J." last="Edwards">Mark J. Edwards</name><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name></country><country name="Slovénie"><noRegion><name sortKey="Kojovic, Maja" sort="Kojovic, Maja" uniqKey="Kojovic M" first="Maja" last="Kojovic">Maja Kojovic</name></noRegion></country><country name="Italie"><region name="Lombardie"><name sortKey="Caronni, Antonio" sort="Caronni, Antonio" uniqKey="Caronni A" first="Antonio" last="Caronni">Antonio Caronni</name></region><name sortKey="Bologna, Matteo" sort="Bologna, Matteo" uniqKey="Bologna M" first="Matteo" last="Bologna">Matteo Bologna</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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